NovoMatrix™ Reconstructive Tissue Matrix

The next generation soft tissue augmentation material

NovoMatrix™ is an acellular dermal matrix derived from porcine tissue. In surgical application, the tear-resistant and easy-to-handle1, 2 ma­trix is an excellent alternative to autologous connective tissue grafts (CTG). There is no need for an intraoral surgical donor site, which reduces morbidity for the patient.

Owing to the manufacturing process, the matrix is free of donor cells. At the same time, the structure of the source tissue remains virtually unchanged, thus supporting the ingrowth of cells and micro-vessels. Proprietary tissue processing enables optimal cell repopulation and revascularization through gentle preparation, resulting in esthetic soft tissue regeneration.3 NovoMatrix™ is supplied pre-hydrated in a paten­ted aqueous phosphate-buffered solution containing matrix stabilizers and can therefore be used promptly without requiring extensive re­hydration.4

NovoMatrix™ Optimal for the following indications4

  • Increase in attached tissue around teeth and implants
  • Reconstruction of the alveolar ridge for prosthetic restoration
  • Guided tissue regeneration in recession defects for root coverage

Recession coverage – tunnel technique

General alveolar ridge augmentation

Tissue thickening around implants and teeth employing the pouch technique

Product characteristics of NovoMatrix™

  • The LifeCell™ tissue preparation process results in rapid revascularization.
  • Consistent tissue thickness at all times
  • Pre-hydrated – ready-to-use out of the package following a 2-minute soak in sterile saline or lactated Ringer’s solution4
  • Storage at -8° C to +30° C4

The NovoMatrix™ tissue structure

Maintenance of graft integrity is essential to achieving successful biological outcomes. NovoMatrix™ is minimally manipulated and processed gently to ensure it retains components critical to maintaining the bio­chemical and biomechanical integrity of the tissue.

Fibrillar Collagen and Collagen VI

Triple-stranded proteins that assemble into fibril complexes to provide structure and tensile strength5


Fibers that function in close association with collagen to provide elasticity and recoil5


High molecullar weight polysaccharide molecules that control tissue hydration, driving water transport and maintaining the elastoviscosity of connective tissues throughout the body5

(large and small)

Large and small macromolecules which guide revascularization and cell repopulation and regulate extracellular matrix structure through assembly and construction6


Complex proteins that mediate a variety of cellular interactions; responsible for modulating cell adhesion, migration, growth, and differentiation7

Vascular Channels

Vessels which provide blood flow trhoughout the matrix, enabling initial revascularization8

Advantages of NovoMatrix™ application

  • Shorter surgery time The ready-to-use collagen matrix shortens surgery time by eliminating the need for a second donor site. 9
  • Lower patient morbidity Avoiding a donor site on the palate eliminates the post-operative pain associated with a second procedure.9, 10, 11
  • Excellent tissue integration The application of NovoMatrix™ supports rapid revascularization, cellular repopulation and minimal inflammatory reactions.3, 8, 12, 13
  • Natural tissue and color structure The application of NovoMatrix™ demonstrates irritation-free healing and very good adaptation of the color and tissue structure to the natural surrounding tissue.14
  • Rapid and complication-free healing of soft tissue The application of NovoMatrix™ supports a positive immunological reaction as well as tissue integration and regeneration.3, 12, 13, 15

NovoMatrix™ live surgical courses

Get to know different surgical techniques when using NovoMatrix™ and let the experienced speakers explain the possibilities of and with NovoMatrix™ to you.

To the NovoMatrix courses

Authors and clinical examples of NovoMatrix™

Priv. Doz. Gerhard Iglhaut

Memmingen, Freiburg University Hospital

Dr. Roman Beniashvili


Dr. Jan Klenke

Dr. Jan Klenke


Andreas van Orten, M.Sc., M.Sc.

Andreas van Orten, M.Sc., M.Sc.


LifeCell™ — over 25 years of experience

Innovative products for tissue reconstruction

For over two decades LifeCell™ has been developing innovative products for a wide range of applications. With over 2.5 million grafts to date, 25 years of experience in tissue processing and an ongoing commitment to innovation, LifeCell™ has joined forces with BioHorizons and Camlog to bring NovoMatrix™, the next generation soft-tissue augmentation material to dentistry.


Foundation of the LifeCell™ Corporation


BioHorizons begins distribution of AlloDerm™ RTM for dentistry (U.S.)


AlloDerm™ RTM for guided bone regeneration (U.S.)


NovoMatrix™ Reconstructive Tissue Matrix for applications in dentistry (EU)*

*NovoMatrix™ is cleared for sale in the European Union.

Success factor processing methods

A breakthrough in the preparation of acellular porcine matrices

Tissue selection

Manufactured from targeted porcine tissue for desired mechanical and handling properties.

Dermis isolation

Non-chemical based method that removes all non-dermal tissue retaining the structu­ral integrity of the matrix.

Microbial neutralization

Proprietary process removes 99.9 % of the pathogens, enabling a more gentle preparation process.

Decellularization & enzyme treatment

Maintains the natural collagen structure while extracting the porcine alpha-gal antigen, as well as the cell and DNA components to minimize the xenogenic immune response.

Matrix preservation

The proprietary preparation process stabilizes the key matrix proteins as well as protecting the integrity of the acellular dermal matrix, thus providing a plat­form for tissue regeneration.


Optimized sterilization process to preserve the natural tissue structure, thus retaining the regenerative properties of the acellular dermal matrix.


An intact acellular dermal matrix derived from porcine tissue that retains the biochemical components that support a positive immunological response and regeneration.12, 16, 17

Histological structure of NovoMatrix™

NovoMatrix™ shows a histological structure comparable to human tissue.12, 16, 17


Human Dermis


  1. Data on file, Allergan. NovoMatrix™ – Mechanical testing, Preclinical Data.
  2. Data on file, Allergan. INT/0204/2018.
  3. Suárez-López Del Amo F, Rodriguez JC, Asa‘ad F, Wang HL. Comparison of two soft tissue substitutes for the treatment of gingival recession defects: an animal histological study. J Appl Oral Sci., 2019;27:e20180584.
  4. Reference manufacturer’s Instructions for Use (IFU) package insert.
  5. Necas J, Bartosikova L, Brauner P, Kolar J. Hyaluronic acid (hyaluronan): a review. Vet Med. 2008;53(8):397-411.
  6. Ludwig MS. Proteoglycans and pathophysiology. J Appl Physiol. 2007;103:735-736.
  7. Pankov R, Yamada KM. Fibronectin at a glance. J Cell Sci. 2002;115:3861-3863.
  8. Harper JR, McQuillan DJ. Extracellular wound matrices: a novel regenerative tissue matrix (RTM) technology for connective tissue reconstruction. Wounds. 2007;19(6):163-168.
  9. Griffin T, Cheung W, Athanasios Z, Damoulis P. Postoperative Complications Following Gingival Augmentation Procedures. J Periodontology 2006;77:2070-2079.
  10. Aguirre-Zorzano LA, García-De La Fuente AM, Estefanía-Fresco R, Marichalar-Mendía X. Complications of harvesting a connective tissue graft from the palate.
  11. Tavelli L, Asa’ad F, Acunzo R, Pagni G, Consonni D, Rasperini G. Minimizing Patient Morbidity Following Palatal Gingival Harvesting: A Randomized Controlled Clinical Study. The International Journal of Periodontics & Restorative Dentistry 38(6):e127-e134 · November 2018.
  12. Sandor M, Leamy P, Assan P, et al. Relevant in vitro predictors of human acellular dermal matrix-associated inflammation and capsule formation in a nonhuman primate subcutaneous tissue expander model. Eplasty. 2017;17:e1-e21.
  13. Xu H, Wan H, Sandor M, et al. Host response to human acellular dermal matrix transplantation in a primate model abdominal wall repair. Tissue Eng Part A. 2008;14(2):2009-2019.
  14. Van Orten A. Peri-implant thickening of soft tissue – stable and functional. Implantologie Journal 5 | 2020.
  15. Sandor M, Xu H, Connor J, et al. Host response to implanted porcine-derived biologic materials in a primate model of abdominal wall repair. Tissue Eng Part A. 2008;14(12):2021-2031.
  16. Data on file, Allergan. LRD2011-08-015.
  17. Data on file, Allergan. LRD2013-02-004.

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